Right now, there's no impetus to trade Ryan Murray. While his time missed due to injuries is a concern, each injury is itself different (so no recurring issues) and would likely have injured any other player. So really they're more bad luck than anything else.
What he does provide is elite defensive awareness and outlet passing. When combined with Jones, Werenski, and Savard, it's easy to see that those four are something a competitive team can be built around.
So really, the only reason to trade Murray would be to address the single hole the Jackets have. Which is a current #1C. We have plenty of top-6 wingers including 2 30 goal guys (Saad and Jenner) plus Atkinson who comes close. We have 2 2nd line quality centers (Wennberg, Dubinsky). We have 5 top-4 defensemen (Jones, Werenski, Murray, Savard, Johnson). And we have a top goaltender (Bob) with 2 really promising young goalies (Forsberg, Korpisalo).
With the Jackets' current cap situation, they're not in a position to trade current assets for futures. So again it really only makes sense if the trade is Murray + for a #1C or Savard ++ for a #1C.