I wouldn't do it. As we sit, we are guaranteed a guy with high potential to become the one thing this franchise has lacked since Sonny -- a bona fide, long-term franchise QB.
I know you like McCarthy, and he may well end up being a very good (yes, possibly even great) QB, but there's really nobody credibly saying he's an almost-can't-miss QB prospect. And it's not even a given that even he would be there at 11 -- we could end up looking at the 5th best QB by then, AND potentially have both the can't miss LTs off the board by then, too.
So I would not give up a pick that's a lock to get a top flight (see what I did there?) QB for 2 picks that in the range where we've generally been picking for the last 10-15 years.