No, not the federation. People who would perceive it as xenophobic to intentionally keep the games away from large metro areas with immigrant populations. I recall some of this sentiment in the past, forget which games in particular. An official move to make a largely white metro area the official home of US Soccer would raise questions.
For the record, I am all for getting as much of a home crowd advantage as you can, outside of outright illegal profiling. This isn't a charity, it's a competition. I come from a Polish upbringing and plenty of my family/friends would root for Poland over the USA despite growing up here or living here since the 1980's/1990's. I would never hold it against US Soccer keeping a meaningful Poland/USA match out of Chicago / NYC metro areas (I know this is really a hypothetical).