The only team that has ever really "blown up" it's roster in recent memory was the Capitals in 2004. They dealt Lang, Gonchar, Jagr, Bondra, Nylander, and Konowalchuk for some spare parts, Laich, Fleischman, and Green.
Nylander had two more ppg season after that trade, Lang had three solid seasons, Gonchar is still a pretty good puck mover, Jagr still an impact forward, Konwalchuk had to retire because of a heart issue (though wasn't slowing down). Bondra was the only one who was pretty much shot by the time they got rid of everyone.
If we're going to get this kind of return for Vanek, Miller, and Pominville I'd rather not go that route. I mean it's always possible that a great deal comes a long for one of them, but its not a certainty. They're our more consistent players and we need more guys like them; not fewer.
I'm ready to move Stafford, Gerbe, Hecht, Kaleta, Regehr, Leopold, Sekera, Weber and Enroth. If they want to chase the #1 pick they will likely be bad enough just by trading depth guys; I don't think they need to move their stars.