General COVID-19 Talk #4 MOD Warning

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These are Sat, Sun, Mon and Today's numbers
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412.75 new cases a day
A nice drop is hosp since Friday 500---> 466
ICU down 10 from Friday
 
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Reading this source, here is a line there:

Individuals who were both previously infected with SARS-CoV-2 and given a single dose of the vaccine gained additional protection against the Delta variant.

I think all the more people should get vaccinated.
Yes they did gain some additional protection. They also were drastically more protected then the vaccinated uninfected group prior to receiving one does of the vaccine.
 
I think you are wrong on the science part and I have tried to show evidence of that to you but you are not interested in it.

I also would love if we had better studies within our country but like I mentioned before the CDC has purposefully decided not to track very important data.


"All of the science points towards vaccination as the way to end this f***ing pandemic so we don't have to walk around in masks and can actually go about our business."

Well which is it? Is it the vaccine or the masks?

Masks and vaccines are different things, it's not either/or. Masks are a temporary solution until everyone gets vaccinated and the virus has nowhere to go. If we were at an 85% vaccination rate, masks wouldn't be necessary for the general public at all. COVID would be a minor thing, not a pandemic.

Vaccines stop COVID, we know this for certain. Reinfection rates are minuscule. We know that vaccines last a while, but boosters may be necessary, just like other vaccines. The COVID vaccines are safer than just about any other medication people take, the risk is extremely low. We know that natural immunity works well for a period of time, but is also susceptible to reinfection. There is no booster for that, and it's why everyone should get vaccinated regardless if they've had COVID or not. If that is done, COVID will be stopped in its tracks. The data for that is just icing on the cake, we've known how vaccines work for over a hundred years. It is really our choice as humans. Do we want to keep this thing dragging or, or do we want it to be a bookmark in history like Polio.
 
I haven't had a chance to look at the whole country but that local data is encouraging and I seem to recall reading over the weekend that the Delta wave is like the other waves in that for whatever reason it sweeps through and declines in 2-3 months so we're on the back end now!
 
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Thanks. That's a preprint. Unfortunately, preprints are popular to get funding for studies because they submit they have an idea for something that is still not vetted and often need further exploration and then vetting. It skips a number of steps and they don't always disclose everything up front because they are seeking funding for grants like biases. Basically, preprints skip the approval process and the steps required to see if the study even holds up, if you want to say vaccines vs natural immunity should be looked at or considered, that's fine but it's certainly not overwhelming evidence and doesn't hold up at this time and prior covid positive individuals should not be vaccinated. I'd rather wait for evidence that has been actually vetted or reviewed before making a policy decision and thus far, the evidence is pointing the other way.

We have to be careful with preprints because in the wrong hands, we can go in a multiple diff directions. Appreciate you submitting the info, but more is needed before accepting the previously stated premise.
I understand how this process works and still find the data incredibly compelling. It is a massive and very thorough study from a country that tracks data related to covid far better then we do. Twice people have posted a study made up (I believe) of 232 people in Kentucky as surefire evidence lol. But I'm willing to roll with it because it's irrelevant to my point.

I provided some excellent data showing that Natural Immunity is not just equal to the current batch of vaccines but is Drastically superior. I'm not surprised that multiple people here are eager to ignore it.

I won't go any further with it, as these type of discussions rarely go anywhere as people are often entrenched idealogically into one position or another.
 
I understand how this process works and still find the data incredibly compelling. It is a massive and very thorough study from a country that tracks data related to covid far better then we do. Twice people have posted a study made up (I believe) of 232 people in Kentucky as surefire evidence lol. But I'm willing to roll with it because it's irrelevant to my point.

I provided some excellent data showing that Natural Immunity is not just equal to the current batch of vaccines but is Drastically superior. I'm not surprised that multiple people here are eager to ignore it.

I won't go any further with it, as these type of discussions rarely go anywhere as people are often entrenched idealogically into one position or another.


All qualms with the methodology aside, that is NOT what it says, no matter how many times you repeat superlatives.

And to accuse others of confirmation bias and hand wave further discussion away after everyone has been, imo, VERY accommodating of your view is pretty gross, but whatever.
 
All qualms with the methodology aside, that is NOT what it says, no matter how many times you repeat superlatives.

And to accuse others of confirmation bias and hand wave further discussion away after everyone has been, imo, VERY accommodating of your view is pretty gross, but whatever.
I think you're coming on a bit strong here...

Am I allowed to use the word drastic when natural immunity is providing 6-13 times more protection? Because people used the word immense to describe 2x more protection lol. But kinda a silly point anyways.

Here is the summary of the results:

"Results SARS-CoV-2-naïve vaccinees had a 13.06-fold (95% CI, 8.08 to 21.11) increased risk for breakthrough infection with the Delta variant compared to those previously infected, when the first event (infection or vaccination) occurred during January and February of 2021. The increased risk was significant (P<0.001) for symptomatic disease as well. When allowing the infection to occur at any time before vaccination (from March 2020 to February 2021), evidence of waning natural immunity was demonstrated, though SARS-CoV-2 naïve vaccinees had a 5.96-fold (95% CI, 4.85 to 7.33) increased risk for breakthrough infection and a 7.13-fold (95% CI, 5.51 to 9.21) increased risk for symptomatic disease. SARS-CoV-2-naïve vaccinees were also at a greater risk for COVID-19-related-hospitalizations compared to those that were previously infected."
 
I think you're coming on a bit strong here...

Am I allowed to use the word drastic when natural immunity is providing 6-13 times more protection? Because people used the word immense to describe 2x more protection lol. But kinda a silly point anyways.

Here is the summary of the results:

"Results SARS-CoV-2-naïve vaccinees had a 13.06-fold (95% CI, 8.08 to 21.11) increased risk for breakthrough infection with the Delta variant compared to those previously infected, when the first event (infection or vaccination) occurred during January and February of 2021. The increased risk was significant (P<0.001) for symptomatic disease as well. When allowing the infection to occur at any time before vaccination (from March 2020 to February 2021), evidence of waning natural immunity was demonstrated, though SARS-CoV-2 naïve vaccinees had a 5.96-fold (95% CI, 4.85 to 7.33) increased risk for breakthrough infection and a 7.13-fold (95% CI, 5.51 to 9.21) increased risk for symptomatic disease. SARS-CoV-2-naïve vaccinees were also at a greater risk for COVID-19-related-hospitalizations compared to those that were previously infected."

The study data are really significant and definitely immense, absolutely warranting a deeper look, I have no problem with using the words you chose. It's still a single study and needs to be replicated, but let's take it as truth.

After reading the full text, I can see why it contradicts many other studies. There is a huge caveat in there - this huge discrepancy is only seen when the infection occurred in January of February of 2021 - right after Delta appeared in late 2020 in India. It indicates that whatever strain was dominant in Israel during the winter peak was probably similar to Delta, hence having great immunity tailored to fight it off. Delta variants would certainly show up there well before here due to proximity. Notice when they went way back to March of 2020, the protection dropped significantly. Given that the high percentage protection period is within the long date range, the drop from 13x to 6x means that for much of that period between March 2020 - December 2020, natural immunity was working less effectively than vaccines. If was doing equally well, the drop would only have been minor. This indicates that Delta is now in the driver's seat.

They also draw a debatable conclusion. They claim this as evidence that natural immunity wanes over time - which is 100% valid. There is another valid conclusion, however, and that is that natural immunity hasn't waned, rather those with natural immunity from 2020 still had robust immune responses, but the antibodies produced by memory cells were far less effective against Delta due to structural differences in binding sites and other variations. This second conclusion would fully explain why earlier studies of different types of immunity always had vaccines coming out on top early - until now we've only had pre-delta dominant data. I don't see anything in their methodology which would preclude this second conclusion, and they certainly don't discount it in their study, which is properly formulated and narrow in scope. A data summary with comparisons of reinfections on a month-by-month basis would have been quite useful. My gut feeling, based on typical viral mutation behavior, is that it's a mixture of both reasons.

What does that mean for us here? Well, Delta showed up in the US in late April, we have been a few months behind Israel and Europe since this thing started. so taking all studies into account, regardless of what conclusion about why immunity drops off is correct:
  • If you were infected in the US before May, you weren't exposed to delta and should definitely get vaccinated. Regardless of whether immunity has waned or it's due to mutation, there is a very high chance your protection isn't nearly as strong as a vaccine which is needed to keep new variants from forming. Assuming you are protected if you got infected during the December peak is just begging for this thing to be dragged out. Every time someone gets infected they risk buying the virus a few more week's time and provide it with an opportunity to change.
  • If you were infected between May and June, you don't have a need to be vaccinated right now. It will provide even more immunity if you do, but unless another variant arises and becomes dominant, your immunity will likely outlast Delta. From their graph, there are some indications that very early infections could provide some resistance to Delta, but this could be anecdotal due to low initial infection rates.
  • If you were infected after June, your immune response will be far more robust than any vaccine, probably outstripping the 13x better protection in this study. Vaccines really shouldn't be an option for these groups, those doses should be used on other groups or in other countries.
 
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More shitty news out of Idaho.

Idaho activates crisis protocol and says some COVID-19 patients may be placed in conference rooms because there are so few hospital beds (msn.com)

I know we bicker over mandates here, but their hesitance to mandate masks has bitten them in the ass up there. There is no reason they should be going through this. Even if they mandate and don't enforce, enough people would probably comply to have avoided this. The Governor has been soft on them, but in return I hope they listen to his pleas to get vaccinated.

Stay safe, dickcheese!
 
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I understand how this process works and still find the data incredibly compelling. It is a massive and very thorough study from a country that tracks data related to covid far better then we do. Twice people have posted a study made up (I believe) of 232 people in Kentucky as surefire evidence lol. But I'm willing to roll with it because it's irrelevant to my point.

I provided some excellent data showing that Natural Immunity is not just equal to the current batch of vaccines but is Drastically superior. I'm not surprised that multiple people here are eager to ignore it.

I won't go any further with it, as these type of discussions rarely go anywhere as people are often entrenched idealogically into one position or another.

I wouldn't go so far as saying that it is drastically superior. There are some problems with the data if you read the comments. If you don't want to go further fine, I will. But keep in mind, this was your assertion to begin with so I'm responding to your assertion.

This is a first glance off what I read.
1. Some demographics are hit much harder than others and the US is more of a melting pot, therefore the data does not cross apply because the US has more of a mix of people who are of different genetic make up and this was not included in the study. According to the CDC peer reviewed data, hispanics and asians and Indians are more likely to get sick and die than Whites which are higher in population in the US compared to Israel. So basically, if you're white, good for you. If you're not, then this data may not apply but that public safety should not be delineating based on origin and if so, how effective are we going to be in determining who should get the vaccine if they are going to get a pass based on a prior infection?
2. This did not take into account comorbidities and how that plays through in reinfection nor does it reference immune compromised. It says it takes them into account but basically means it tweaked its numbers so the question is, did they cut the patients with commorbidities or create a separate algorithm? What happened there? It renders the conclusion too narrow in scope or unexplained and is a gap in the data submitted as it is, nor are breakdowns provided.
3. This only studied one vaccine insofar as a 2 dose regimen. It did not study a 3rd. Note that some vaccines require 3 doses like Hep B. The first two are 30 days apart, the next one six months after. We don't have the data yet and this is only up to present so it is easy to determine this is inconclusive or limited in scope based on the information provided and further study is needed since we are entering a 3rd phase based on Pfizer's and Moderna's recommendation.
Furthermore, there was another study that the same authors of this preprint did referencing boosters and how they are much significantly effective but does not compare that with the prior study, you can start with Sivan Gait.
4. This only studies the Delta variant post infection. There are other mutant variants out there that are unaccounted for and unexplored. What happens with the other variants if they become dominant? How does that play into the decision making since this is an evolving virus, keeping in mind that it is possible to get Covid more than once and each variant has a different degree of separation from the original.
5. The conclusion also acknowledged that getting one dose of the vaccine provided strong immunity after infection when combined but never quantified that data. 2 follow up questions.
5a Why not? Is one dose post infection perhaps stronger than natural immunity? It blew right past that which makes me wonder why they stopped there. It just ended like a bad joke. I characterize it that way because you are hinging your entire argument on that it is not necessary if one is post infection and this study fails to not only examine it deeper, but it acknowledges it and then sweeps the info under the rug.
5b Why did it not study 2 dose vaccination post infection and it studied only one? What would the data show if it did? Why is it posting a side by side and not doing a study on post infection and post 2 dose vaccination to determine if there was an even better method for increased immunity. As current data suggests outside of this study, 2 dose vaccination post infection is much higher.

I can go on but this is exactly why peer review exists.

These are simple questions asked during a peer review process that should be answered before making a policy decision or guiding policy for government entities to consider. Just looking at it and saying well the data is massive really doesn't cut it when people's lives are at stake. We don't lick our fingers and stick it in the air when it comes to public health but for some reason we do that with individual patients sometimes. However, in this case, we're talking populations of people who could/would suffer if your idea was enacted because it hasn't been vetted. There are questions attached to a peer review that study the data collection, analysis and conclusions and then the raw data which would bring even more questions. I could never show up with a preprint and expect to role out a new policy and have it fly without it going through the proper steps. Everything has to be peer reviewed in both medicine and public health, otherwise you get Hydroxychloroquine causing your patients to got into VTAC because someone saw it on TV and demanded to put their family member through it even though it was already shown not to stand up.

So basically, the information is interesting at best but does has some gaps at first glance. It's not about personal bias, it's about making sure that decisions keep people safe and moreover, help this country move forward. Public safety is the highest priority.

Going back to your original argument now, the FDA approval is in place, private businesses are going to have employees demanding a safe working environment and there will be lawsuits when it can be shown that a company did not do enough to protect its employees. They will also pay with attrition at work as well as having to rehire new employees, which costs a lot of money and irreplaceable time and resources. In addition, the costs from health insurance companies and life insurance companies will go up on those who are unvaccinated since they will be more expensive to treat as COVID patients require more resources in the hospital and frankly they should be because the costs to take care of them are overwhelming. My patient last night was on 3 drips, noncovid. My neighbor's patient was on 12 drips, COVID. Some of those drips have to be compounded and double checked in pharmacy and that costs a ton of money that someone is going to have to pay for and the hospitals are not going to take it up the rear here because they have investors to answer to and employees to pay. So if you're asking why vaccine mandates should exist, it is basically difficult to verify prior infection and we have already seen the public in their openness to share public health info. They stand on top of it like a rock and then hide in its shadow. Basically we don't trust people to do the right thing which is why we have vaccine cards to prove it to begin with to attend school, college, certain jobs etc. This is no different.

I apologize if this comes across as harsh but I wanted to be thorough and also, I just finished my 2nd night shift and I have one more to go. No malintention on my part or hard feelings your way, I'm just answering the argument as dry as I can and sticking to the points of the argument itself. No personal attack intended.
 
Well, I got married at the end of August. We planned our wedding COVID-proof in that we did our best to not have a superspreader event and also to not get it canceled for the second year in a row. We had the ceremony at the beach here in Long Beach and then a backyard party at a friend's house.

Of course while vacationing in Maui the following week we start getting a bunch of text and phone calls of people who got sick and tested positive. We're still not sure if the party was what caused it or if maybe a few people caught it there and there were a few separate incidents. What is incredibly strange and leads me to believe there may be multiple coindinces is that not a single one of my friends or family got sick. By the way, pointing that out did me no favors. Great job, detective! Sometimes it's good to keep your mouth shut.

Most of the people that did get sick were vaccinated although most of the ones that weren't vaccinated had gotten COVID already. Everyone appears to be on the mend so that is good and none of the people with severe underlying conditions or older in age got sick. But it definitely put a damper on being in Maui particularly because we didn't want to potentially make things worse there. The day we landed was the day the Governor told people to stop coming there... LOL! What a f***ing year and half this has been. Will it ever end?
 
I wouldn't go so far as saying that it is drastically superior. There are some problems with the data if you read the comments. If you don't want to go further fine, I will. But keep in mind, this was your assertion to begin with so I'm responding to your assertion.

This is a first glance off what I read.
1. Some demographics are hit much harder than others and the US is more of a melting pot, therefore the data does not cross apply because the US has more of a mix of people who are of different genetic make up and this was not included in the study. According to the CDC peer reviewed data, hispanics and asians and Indians are more likely to get sick and die than Whites which are higher in population in the US compared to Israel. So basically, if you're white, good for you. If you're not, then this data may not apply but that public safety should not be delineating based on origin and if so, how effective are we going to be in determining who should get the vaccine if they are going to get a pass based on a prior infection?
2. This did not take into account comorbidities and how that plays through in reinfection nor does it reference immune compromised. It says it takes them into account but basically means it tweaked its numbers so the question is, did they cut the patients with commorbidities or create a separate algorithm? What happened there? It renders the conclusion too narrow in scope or unexplained and is a gap in the data submitted as it is, nor are breakdowns provided.
3. This only studied one vaccine insofar as a 2 dose regimen. It did not study a 3rd. Note that some vaccines require 3 doses like Hep B. The first two are 30 days apart, the next one six months after. We don't have the data yet and this is only up to present so it is easy to determine this is inconclusive or limited in scope based on the information provided and further study is needed since we are entering a 3rd phase based on Pfizer's and Moderna's recommendation.
Furthermore, there was another study that the same authors of this preprint did referencing boosters and how they are much significantly effective but does not compare that with the prior study, you can start with Sivan Gait.
4. This only studies the Delta variant post infection. There are other mutant variants out there that are unaccounted for and unexplored. What happens with the other variants if they become dominant? How does that play into the decision making since this is an evolving virus, keeping in mind that it is possible to get Covid more than once and each variant has a different degree of separation from the original.
5. The conclusion also acknowledged that getting one dose of the vaccine provided strong immunity after infection when combined but never quantified that data. 2 follow up questions.
5a Why not? Is one dose post infection perhaps stronger than natural immunity? It blew right past that which makes me wonder why they stopped there. It just ended like a bad joke. I characterize it that way because you are hinging your entire argument on that it is not necessary if one is post infection and this study fails to not only examine it deeper, but it acknowledges it and then sweeps the info under the rug.
5b Why did it not study 2 dose vaccination post infection and it studied only one? What would the data show if it did? Why is it posting a side by side and not doing a study on post infection and post 2 dose vaccination to determine if there was an even better method for increased immunity. As current data suggests outside of this study, 2 dose vaccination post infection is much higher.

I can go on but this is exactly why peer review exists.

These are simple questions asked during a peer review process that should be answered before making a policy decision or guiding policy for government entities to consider. Just looking at it and saying well the data is massive really doesn't cut it when people's lives are at stake. We don't lick our fingers and stick it in the air when it comes to public health but for some reason we do that with individual patients sometimes. However, in this case, we're talking populations of people who could/would suffer if your idea was enacted because it hasn't been vetted. There are questions attached to a peer review that study the data collection, analysis and conclusions and then the raw data which would bring even more questions. I could never show up with a preprint and expect to role out a new policy and have it fly without it going through the proper steps. Everything has to be peer reviewed in both medicine and public health, otherwise you get Hydroxychloroquine causing your patients to got into VTAC because someone saw it on TV and demanded to put their family member through it even though it was already shown not to stand up.

So basically, the information is interesting at best but does has some gaps at first glance. It's not about personal bias, it's about making sure that decisions keep people safe and moreover, help this country move forward. Public safety is the highest priority.

Going back to your original argument now, the FDA approval is in place, private businesses are going to have employees demanding a safe working environment and there will be lawsuits when it can be shown that a company did not do enough to protect its employees. They will also pay with attrition at work as well as having to rehire new employees, which costs a lot of money and irreplaceable time and resources. In addition, the costs from health insurance companies and life insurance companies will go up on those who are unvaccinated since they will be more expensive to treat as COVID patients require more resources in the hospital and frankly they should be because the costs to take care of them are overwhelming. My patient last night was on 3 drips, noncovid. My neighbor's patient was on 12 drips, COVID. Some of those drips have to be compounded and double checked in pharmacy and that costs a ton of money that someone is going to have to pay for and the hospitals are not going to take it up the rear here because they have investors to answer to and employees to pay. So if you're asking why vaccine mandates should exist, it is basically difficult to verify prior infection and we have already seen the public in their openness to share public health info. They stand on top of it like a rock and then hide in its shadow. Basically we don't trust people to do the right thing which is why we have vaccine cards to prove it to begin with to attend school, college, certain jobs etc. This is no different.

I apologize if this comes across as harsh but I wanted to be thorough and also, I just finished my 2nd night shift and I have one more to go. No malintention on my part or hard feelings your way, I'm just answering the argument as dry as I can and sticking to the points of the argument itself. No personal attack intended.
I don't mind going further I just don't want to bombard this message board with studies and information that isn't wanted here. Honestly my main point isn't that Natural Immunity from Covid is much better than the vaccine. Its that it's at worst very comparable. In order to make that point I am using a massive study from a country that frankly has far better data on this then we do, because the CDC in our country decided that it was no longer important to track breakthrough infections, which is mind boggling when we are trying to take a scientific approach to this.

Im not going to go point by point to defend this study because it won't go anywhere if I do.

Lets just keep it simple and say they took tens of thousands of people from 3 groups and then compared their tests over time.

1 group was people who were fully vaccinated but had no prior covid infection. A 2nd group had been previously infected but had not been vaccinated. A third group had been infected and received one dose of the vaccine.

They then looked at the test results from each group and what they found was that the 2 previously infected groups ALWAYS had far less positive tests, symptomatic cases and hospitalizations then the fully vaccinated group that had no prior infection.

What they also found was that the prior infected groups immunity also held up for much longer then the fully vaccinated group whose immunity waned much quicker so this advantage in protection became even more dramatic as more time passed.

Maybe it's the genetic makeup of Jewish people... Or maybe it's a fake news story, or there were massive flaws as many of you are desperately claiming. But I don't believe that's the case and you do. I don't think we will change each other's minds on this.

I will just stick to my main point which is that people with natural immunity should be treated at worst equal in terms of freedoms as people who are vaccinated. Because it is highly unlikely given what we have always known about natural immunity that (once acquired) it does provide strong immunity. .
 
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The jab is an extra weapon in the fight against COVID. The Israeli study says this exact statement. Not getting vaccinated is like playing goal with a jock strap missing the cup.

Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections

Nobody is disputing that there is additional protection provided from getting the vaccine lol. But you and others seem to be purposefully missing the point here...

I think what is going on here is that you and others are making an argument now that says getting the covid vaccine is good for everyone. That is separate from my point and irrelevant, I also have not made any claims against that.

The discussion is simple: should I and others (who have been previously infected) be forced to get multiple shots of a vaccine at the point of losing our jobs and basic freedoms?

People who want to force a large segment of people with natural immunity into still getting vaccinated are almost forced into believing that having natural immunity is not nearly as effective as having a vaccine. And because they have been misled into believing this is the case they are very confused when presented with evidence that says the exact opposite is true and falling back on finding other reasons why they can discount it and still be able to force the vaccine upon other people.

The reality is that Natural Immunity is highly effective and always has been.
 

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