Just to follow up on what
@NotABadPeriod posted:
I can't stress enough his point to know the format of the league and the scoring system. If your league gives a point or half-point per reception -- that's going to make WRs more valuable than RBs early, and that deepens the number of playable RBs. Also watch how many points per TD throw. If it's 6 points per TD throw, consider taking your QB a little earlier than some sites would recommend (the default is 4 points per TD throw anymore).
Just to kind of give you an idea of what you could be in for, I just drafted in a 10 team league last night. 1 point per reception, 4 points per TD throw. My team wound up being (and the round):
QB -- Herbert (7), Prescott (10)
RB -- Etienne (3), Mattison (6), Kamara (9)
WR -- Diggs (1), Kupp (2), Hopkins (5), McLaurin (8), Smith-Schuster (12), Toney (14)
TE -- Andrews (4), Higbee (13)
D/ST -- New Orleans (11)
K -- Whothehellcares (15)
This is just one example.