I mean, usually a guy that requests a trade gets traded. So we’ll see.
The 49ers didn't trade Samuel when he requested one in a more or less identical position. Barring the sort of all time sulk that should make teams reconsider whether they actually want Aiyuk, I don't see why they'd handle it differently.
edit: Just to expand on this -
The 49ers had to have thought through all the scenarios when they decided not to trade Aiyuk at the draft, right? Including the real possibility they couldn't get a contract done until a long way through the summer, if then?
If they decided that was the better course then, why change their minds? A trade request had to be one of the scenarios they brought up and decided they could live with.
They're in a championship window. There's no deal they can strike that'll make them stronger this season. They'll still have control over Aiyuk next season through the franchise tag.
The only real reason I see for them to change their mind is Aiyuk getting stupidly unhappy, or a stupidly big trade offer. And a trade request isn't the former.