Nylander and Matthews have played together for forever. I doubt Nylander plays with Tavares and Marner plays with Matthews. Honestly, though a lot of speculation is that part of the pitch to get him was that Tavares would play with Marner, I wouldn't be surprised to see the following:
Hyman-Matthews-Nylander
Marleau-Tavares-Kapanen
Johnsson-Kadri-Marner
Kadri and Marner played well together down the stretch last year, and Kapanen gets to play with two veterans to shield him for his first full season. As well, Babs can still move Nylander and Brown in and out for each other when that line is struggling a bit, which he does a lot.
Really, though, it doesn't matter much what the line combos are, because even the most absurd set of lines you could think of would be insane.
I'm with people that say you keep the forward core together as long as you can and let the defense work itself out in the system, especially now that Doughty is locked up long-term. Just get rid of Gardiner for some bags of pucks and give Dermott, Rosen, Holl and Borgman the chance to show they belong.