In the comics she does return after biting the bullet.Pretty much this. My guess is that the events of Loki will be the setup/motive for Kang stepping into he forefront where he'll be teased in the final episodes. While the MCU's shows are not key components of their storyline in comparison to the movie (allegedly), they provide some important character developments and will help explain some actions/motives in the movies.
My guess:
Ravonna is killed by the Loki's and as the TVA crumbles, this sets up Kang's motive to engage a war. Losing his love and control over the timeline sends Kang on a vengeful rampage to regain control on the multi-verse.
I think this show out of all of them, will lead the most into the next Doctor Strange movie. With the potential return of the multiverse and that would lead to the first mention of mutants etc. down the line.