There's a couple notable misses in Anaheim's history that in hindsight, you kinda wonder what other option they would have had. Like there's enough other misses around Anaheim's picks that even if the Ducks didn't draft the guy they did, the other reasonable options don't seem much better.
2006 was Mark Mitera at 19 - Only four players in the next 13 picks played more than 80 games. Claude Giroux was picked three picks later but was viewed as a reach (THN had him 60th in their mock). Varlamov was a first rounder to Washington, but the Ducks (with Giguere and Bryzgalov) weren't looking for that type of goalie talent, Berglund played over 700 games but infamously bailed on Buffalo shortly after being dealt and Nick Foligno has stuck around in various roles. I think I had Anaheim projected for Sanguinetti that year in the HF mock draft; he at least made it to the show, but only for 45 games.
2014 was Nick Ritchie at 10 - he played almost 500 games, but players like Fiala, Larkin, Tuch, Schmaltz, McCann, Pastrnak and Kempe all drafted within 20 slots after him. I remember being at the Combine that year and the story was that Anaheim was high on Kasperi Kapanen, but when the draft came around, the narrative was that Ritchie fell (Sportsnet and Bleacher Report both had him projected to go 7th overall).
2015 was Larsson at 27 - he played most of three seasons with the Ducks. Immediately after him was Beauvillier who is now on his fifth team as a depth forward. Sebastian Aho at 35 (the Hurricane one) would be the next highlight, but not a significant amount of "oh dang!" over the next 20 picks. I guess depending on how much you like Travis Dermott, Brandon Carlo and Erik Cernak. All of them defensemen who have stuck around in the league longer.
2016 was Jones (24th) and Steel (30th) - Tage Thompson at 26 makes this one look worse, but after that were looking at Jordan Kyrou at 35 and Alex Debrincat at 39.