The offensive difference between Nurse and Makar is not greater then the difference between McDavid and Mackinnon. Nurse is also more physical and better defensively.
This is McDavid and Nurse for me.
His defensive impact is much, much worse than Makar's. The offensive difference will also be huge once Nurse's shooting percentage regresses. I fully expect Makar to outscore Nurse by 30+ points and might even double him. Hell, this year, Makar paced to outscore Nurse by 29 over a full season. Granted Nurse is limited by PP time, but he also hasn't shown to be very good there.