Absolutely not.
Seguin does not posses the defensive skills necessary to play the Center position let alone the 1st line Center position.
If you move the lines, Segin goes to back with Looch and Krejci and you remove Bourque and put Pandolfo in his spot and keep Kelly at Center which opens Peverley up to utilize his speed and offensive abilities.
I can't see Bourque out and Pandolfo in as anything close to an improvement. Then Peverley has to carry Kelly who has shown no offensive upside this season and Jay Pandolfo who I believe has 23pts in the past two seasons.
If you're going to juggle the lines, with Thornton's current play I would even say to sit him and bring Spooner back up from Providence for more creativity on line three.
Lucic - Krejci - Horton/Seguin
Marchand - Bergeron - Seguin/Horton
Bourque - Peverley - Spooner
Paille - Kelly - Campbell
Now you have Kelly in his proper role, Julien has a really awesome defensive line that he can roll out against anyone and Peverley has some creativity on either side of him to work the offensive zone. Come deadline time ideally we bring in Jagr/Whitney/Ryder, etc. and slot them in next to Bourque and Peverley.