Thanks for the replies and suggestions all. Sitting at the airport now after a great week.
We had a nice little Airbnb in Leslieville - it reminded me a lot of a neighborhood I used to live in in DC, and it was a great jumping off point.
Highlights were definitely the HHOF and the game Wednesday. Easy to spend hours at the HHOF. Wandered in St Lawrence to kill some time in between. Went to Duke's after.
Laughed a ton at Second City. Can't recommend that enough if you haven't done it, I'd seen their show in Chicago before.
We went to The Rex and Jazz Bistro for music, recommendations from a musician friend who plays Toronto from time to time.
Very much enjoyed the ROM, in particular the First People exhibit and the photographer of the year photos.
Too much good food and drink to list.
Thanks again. We'll have to plan a trip back in the summer