World Issues is U.
I'll get a high 60/low 70 in chem.
I went for Business Admin and my 6 I believe were World Issues, Exercice Science, Accounting, Business, Politics and Economics. (Calculus was a year away from being needed, as opposed to recommended)
They don't look at your courses for top 6, if Accounting is your top choice (unless you need a specific course or two)
Obviously if you want to cover yourself, take the chemistry and put in the extra effort.
Personally, World Issues was a pretty interesting course, and easy to do well in.