Babcock doesn't adjust well at all - so I wouldn't count your coach out.
Matthews is also playing pretty pedestrian at the moment - speculation is he is still hurt. Marner is coming online but is extremely snakebitten. He's also a playmaker who only has one threat on his line (Matthews), and if speculation is true - that 1st line will be teethless.
The 2nd line could be an issue. JvR adds a threat around the net and Kadri and Komarov like to play a heavy, overload type style. Kadri's pretty slow, though, so your forwards shouldn't have much trouble keeping up (or blitzing in case of McDavid). I expect Komarov shadows McDavid.
3rd line is toothless. Marleau is basically a non-threat at this point. Doesn't really do much. Bozak is a liability in almost all facets of the game outside of faceoffs. He had his best game in a long time against Calgary so he might be coming online but I doubt it. Brown will tailor his game and bring a defensive presence. Don't expect much offence from this line. It has good speed but no real setup ability and the finishing from Marleau has been absent most of the year. Brown cannot carry a line and that is what he is going to have to do here.
4th line could be a problem with Nylander. His options of Martin and Moore don't lend much to the ability for setups, so it'll rely on him finishing and he's been in a horrible drought. Money is you won't even pay attention to this line much. The ability to score exists though. Having a player with Nylanders skillset hidden on the 4th could be boom or bust. Given his play lately - more likely bust.
Overall, I think your team takes it with a shutout.