Wingers, sure, but it is nearly impossible to get a franchise center outside of the top-5 of the NHL draft and those players do not get moved. Thornton and Eichel are the only ones in the last 20 years, and Eichel had circumstances.
Meanwhile, like 50% of legitimate #1 NHL defensemen come from outside the top-10 of the draft, and most from outside the top-5. You aren’t wrong that it’s harder and takes longer to develop them, but the point is that you don’t need a top-5 pick to get a #1D and you very much do to get a true franchise center.
Edmonton traded for Ekholm and Walman and got Bouchard at like 8th overall. Carolina got Slavin outside the first round. Harley, Karlsson, and Morrissey were mid-1st round picks. Florida got Forsling off waivers and traded for Jones. Hughes was taken 6th and is better than the defenseman drafted 1st overall in his draft year (Dahlin). Fox wasn’t a 1st round pick. Jackson LaCombe came out of nowhere, Brock Faber was a second round pick, Roman Josi too, Mackenzie Weeger was like a seventh rounder. Obviously your Doughtys, Hedmans, Dahlins, Heiskanens, and Makars were top-5 picks, but the point is that a lot of true #1D are acquired outside the premium draft spots.
Meanwhile, star centers are not. Here’s every single NHL center I could think of who is, has been, or may become true #1Cs, and I went very liberal on the definition of “true #1C” to prove the point (bolded are guys I think are undeniable):
Top-5:
McDavid
Matthews
Mackinnon
Draisaitl
Crosby
Malkin
Toews
Backstrom
Hughes
Hischier
Pettersson
Bedard
Carlsson
Fantilli
Celebrini
Beniers
McTavish
Stutzle
D. Strome
Eichel
Tavares
Duchene
Cooley
Smith
Byfield
Top-10:
Scheifele
Kadri
Zibanejad
Horvat
Lindholm
Monahan
Couture
Rest of 1st round:
Kopitar
Suzuki
Thomas
Barzal
Larkin
Miller
Johnston
Thompson
Hertl
2nd or later:
Aho
Hintz
Point
Bergeron
Basically, it’s nearly impossible to get franchise centers outside of the top-5 of the NHL draft. So there is an opportunity cost associated with drafting a defenseman in the top-5 if there is a potential star centerman available. And in short, that is the only reason the Isles may (and should seriously) consider Misa over Schaefer.