Somebody has gotta be willing to pay for it, though. It essentially comes down to 2 factors: (1) can Detroit live without a defenseman if they get another pick? (2) Do Vancouver, Chicago, or NYR have a strong preference for which defenseman of that group they end up with? Strong enough a preference to give up a valuable asset for it?
I just don't see it happening. Vancouver could pay, but they're close enough that they could get a really comparable player. Chicago will be really, really hesitant to give up a 2nd considering they're trying to stock up on cheaper guys to offset their grossly overpaid stars. NYR could be in the mix, but I think this would be the least appealing option for Detroit. They would have to really pony up, because a trade with NYR could mean Detroit is locked out of that elite group of defensemen.
For this to happen, a team is going to have to basically be obsessed with that defenseman. Like if Hughes is there and they think Hughes is substantially better than, say, Dobson. Or vice versa. But it's sorta like the HFBoards rumor section effect: the fact that you are so willing to deal reflects the value of your asset. So if Detroit thinks these guys are similar enough that there's value to be had by moving the pick, it's highly likely that other teams think they're similar, as well, and so they probably won't want to trade up.